Integrative Ecophysiology studies in our group aim to understand and predict the effects of the multiple stressors (such as the global climate change, hypoxia and other anthropogenic stressors) on marine organisms. We focus on energy homeostasis as a central mechanism setting limits to the organisms’ stress tolerance and develop approaches to predict the fate of the populations based on the effects of the environmental change on the energy balance. To this end, we investigate the stressor effects on mitochondrial function, cellular metabolism and stress responses and link them to the fitness consequences (survival, growth and reproduction) at the whole organism level.